Use of the IGF-Trap as a Therapeutic Agent
| Period from: | 2008-11-01 to 2009-10-31 |
| Principal Investigators: | Dr. Pnina Brodt |
| Co-Investigators: | Bernard Massie |
| Institution: | McGill University |
| Department: | Surgery, Medicine & Oncology |
| Program: | Pilot Research Project |
| Abstract: |
The objective of this study is to engineer a novel, soluble IGF-I receptor (the "IGF-Trap") as a drug for prevention and treatment of cancer metastasis. A protein engineering system based on adenoviral vector-infected Chinese hamster ovary (CHO) cells will be optimized for production of high soluble protein yields and the protein will be purified and tested in pre-clinical models of liver metastasis. Drug dose and scheduling will be optimized to produce a maximal therapeutic effect in the pre-clinical setting. It is hoped that this study will lay the groundwork for seeking regulatory approval to advance this drug candidate into the clinic.
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| Funding Information: | |
| 2008-2009 | $44,792 |
| 2009-2010 | $62,708 |
| TOTAL | $107,500 |
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