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Request For Applications
The Terry Fox New Frontiers Program Project Grants (2016)


A Terry Fox New Frontiers Program Project Grant provides support to a group of researchers conducting independent high-quality investigations in a complex area of cancer research. The purpose is to stimulate group interaction based on the premise that high impact work in complex areas of cancer research requires collaboration. The Terry Fox New Frontiers Program Project Grant is designed for researchers with complementary skills, who investigate different aspects of a given cancer relevant topic, the results of which will be realized more rapidly and efficiently than if the individual projects were to be funded as a series of independent operating grants. This long-standing funding opportunity has supported many of the best cancer research groups in Canada.


To explore new frontiers in cure-oriented cancer research by means of a group research grant.


Support under this RFA is for multidisciplinary programs of excellence that contribute to well-defined research topics of relevance to cancer. The goal of each innovative and independently fundable research project and technologies that comprise a Terry Fox New Frontiers Program Project Grant (PPG) is to provide new knowledge with the potential to transform cancer diagnosis, treatment and/or understanding of cancer biology. Proposals which address fundamental issues such as (i) hard-to-treat cancers, (ii) metastatic disease, (iii) mechanisms of disease progression and/or resistance, or (iv) cancer stem cells are welcomed in addition to other cancer-relevant topics.

Support offered

This RFA supports programs comprised of a minimum of three independent researchers and their research projects, and may also include one or more technology platforms that will be used by the projects. Support is offered, commencing on July 1, 2016, for:

  • New Applications of up to $750,000 per annum for a maximum of three years, and
  • Renewing Applications of up to $1,500,000 per annum for a maximum of five years.

Key Deadlines

Stage Dates Status
Submission of a Letter of Intent July 2, 2015 (5:00 pm PDT) Closed
Invitation to Submit a Full Application September 18, 2015 Complete
Submission of a Full Application November 16, 2015 (5:00 pm PST) Complete
Site Visits Held April 2016 Complete
Notice of Decision/Awards May 27, 2016  
Funding Starts July 1, 2016  


Guidance provided


Summary of Letter of Intent Stage

As described in the competition Request for Applications (RFA), The Terry Fox Research Institute (TFRI) has created a Program Project Grant Steering Committee on Research Excellence (PPG SCORE) which will oversee this year's competition. The committee reviewed 17 letter of intent (LOIs) applications on Wednesday September 9, 2015 in Toronto. All LOIs received were from established cancer researchers proposing to study important cancer questions in novel and innovative ways. The committee has recommended that seven LOI teams be invited to prepare full applications. The competition envelope is currently capped at $15 million (or $3 million per year) which will be sufficient to fund two or three programs. The teams invited to apply are:

Program Title Project Leader
Overcoming Treatment Failure in Lymphoid Cancer Connors, Joe
Targeting the Adaptive Molecular Landscape in Castrate-Resistant Prostate Cancer Gleave, Martin
Lung Cancer Screening Lam, Stephen
Slaying the Nemean lion – towards breast cancer precision medicine Lupien, Mathieu
Targeting clonal heterogeneity in treatment-refractory glioblastoma Singh, Sheila
Targeting the Hippo signaling pathway in cancer Wrana, Jeff
Integrated Molecular Analysis of Small Renal Masses for Identification of New Biomarkers and Therapeutic Targets Yousef, George

For inquiries, please contact:

Russell Watkins
Terry Fox Research Institute | l'Institut de recherche Terry Fox
675 West 10th Avenue
Vancouver, BC V5Z 1L3 CANADA
Telephone: 1-604-675-8000 ext 7624
Email: rwatkins@tfri.ca

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